News Release 

UM researchers publish study on genomics of pregnancy-induced diabetes

By a team of researchers from the Faculty of Medicine & Surgery at the University of Malta

University of Malta

Research News

Pregnancy-induced diabetes, also known as gestational diabetes, is a common metabolic complication of pregnancy. The disorder carries a significant risk of adverse obstetric outcome. Additionally, it is associated with a high risk of recurrence, progression to maternal type 2 diabetes as well as an elevated risk of obesity in foetuses exposed to hyperglycaemia during gestation.

The mechanisms causing gestational diabetes are complex and incompletely understood. The disorder has a strong underlying genetic element that interacts with lifestyle factors and the physiologic changes accompanying pregnancy to alter maternal glucose regulation.

A team of researchers from the Faculty of Medicine and Surgery have applied high-throughput genomics to identify rare highly-penetrant genetic variants that drive the development of gestational diabetes.

The study, entitled 'Screening for monogenic subtypes of gestational diabetes in a high prevalence island population - a whole exome sequencing study' provides the first description of atypical diabetes presenting in pregnancy in the Maltese population.

This research integrates clinical medicine, genomics and protein modelling with longitudinal follow-up data. The paper highlights the genetic heterogeneity underlying disorders of glucose regulation and reinforces the role of precision medicine research in unravelling the aetiology of complex traits.

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The authors of the study are Dr Nikolai Paul Pace, Ms Barbara Vella, Dr Johann Craus, Dr Ruth Caruana, Prof. Charles Savona-Ventura and Prof. Josanne Vassallo.

The study was supported by a Research Excellence Grant from the University of Malta.

The study has been published in Diabetes Metabolism Research and Reviews and is accessible online: https://doi.org/10.1002/dmrr.3486

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