T-cell biomaterial control of recurrence following surgical resection. T(A) (i) MOC1-ova tumors were established in immune competent C57BL/6 mice and underwent IT administration of tumor-specific OT1 T-cells or non-specific 2C T-cells in 30 μl of Matrigel into the tumor, or subcomplete resection and administration of the same biomaterials into the resection cavity. Graphs show (ii) average tumor size for all groups (iii) recurrence for resection groups, and (iv) overall survival of all treated mice. (B) (i) Immune competent mice bearing MOC1-ova tumors underwent surgical resection and administration of T cell biomaterials into the resection cavity as per a). Mice were randomized to receive no further treatment or 3 weekly doses of adjuvant anti-PD1 starting 5d following resection. Graphs show average tumor size for (ii) T-cells alone or (iii) T-cells plus adjuvant anti-PD1. Graphs show (iv) recurrence following resection, and (v) overall survival of treated mice. Abbreviation: NS: not significant. *p < 0.05, **p < 0.01.
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