
Oncotarget: Response to neoadjuvant chemotherapy in locally advanced breast cancer
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Pre-treatment T2-weighted MRI texture features can predict NAC response with reasonable accuracy.
Anti-LAT1 monoclonal antibodies significantly inhibited in vitro cell proliferation and in vivo tumor growth of naLAT1/3T3 cells in nude mice, demonstrating LAT1 to be a promising anti-cancer target
These Oncotarget data demonstrate that local delivery of tumor-specific T-cells is an efficient option to convert tumors that are unresponsive to checkpoint inhibitors to permit tumor cures.
The authors developed and analytically validated a new droplet digital PCR -based assay for HPV16 circulating tumor DNA
In 2018, there were over 2 million cases and 0.6 million deaths from breast cancer (BC), making it the most common cancer globally among women.
Climate change is exacerbating human-wildlife conflicts by straining ecosystems and altering behaviors, both of which can deepen the contacts -- and potential competition -- between people and animals. In an article published July 30 in the journal Science, Briana Abrahms, a University of Washington assistant professor of biology, calls for expanding research into the many ways that climate change will impact the complex interplay between human activities and wildlife populations.
In 2019, a coalition of more than 11,000 scientists from across the globe declared a climate emergency and established a set of vital signs for the Earth in order to measure effective climate action. Now, twenty months later, a new study published today in BioScience finds that those indicators -- including ice and forest loss, ocean acidity, and global temperatures -- reflect the consequences of unrelenting "business-as-usual" on climate change.
Twenty months after declaring a climate emergency and establishing a set of vital signs for the Earth, a coalition headed by two Oregon State University researchers says the updated vital signs "largely reflect the consequences of unrelenting business as usual."
This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas.
Taken together these Oncotarget findings show that the CTD and OD domains of mtp53 R273H play critical roles in mutant p53 GOF that pertain to processes associated with DNA replication.