UC San Diego School of Medicine researchers discovered gene expression patterns associated with pandemic viral infections, providing a map to help define patients' immune responses, measure disease severity, predict outcomes and test therapies -- for current and future pandemics.
A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia. The findings, published in Alzheimer's Research & Therapy, indicate an overlap between COVID-19 and brain changes common in Alzheimer's, and may help inform risk management and therapeutic strategies for COVID-19-associated cognitive impairment.
An international team of researchers have shed new light on the early stages of viral evolution.
The term 'wet market' is often laced with negative undertones, especially in light of the COVID-19 pandemic, but the majority of these markets -- like the one featured above in Taipei, Taiwan -- pose very little risks to human health and biodiversity, according to a new study by Princeton University researchers.
The COVID-19 pandemic has made clear the importance of understanding precisely how diseases spread throughout networks of transportation. In a paper publishing on Thursday in the IAM Journal on Applied Mathematics, Stephen Kirkland (University of Manitoba), Zhisheng Shuai (University of Central Florida), P. van den Driessche (University of Victoria), and Xueying Wang (Washington State University) study the way in which changes in a network of multiple interconnected communities impact the ensuing spread of disease.
Evidence suggests auditory and vestibular effects should be added to the growing list of physiological impacts of COVID-19. During the 180th Meeting, Colleen Le Prell from the University of Texas at Dallas will talk about hearing and balance disorders associated with coronavirus infection and how pandemic-related stress and anxiety may aggravate tinnitus symptoms. Her presentation, "Hearing disorders secondary to infection with SARS-CoV-2," will take place Thursday, June 10.
The WHO and the CDC recommend keeping a certain distance between people to prevent the spread of COVID-19. These social distancing recommendations are estimated from a variety of studies, but further research about the precise mechanism of virus transport is still needed. In Physics of Fluids, researchers demonstrate normal breathing indoors without a mask can transport saliva droplets capable of carrying virus particles 2.2 meters in 90 seconds.
UC San Diego School of Medicine researchers discovered that SARS-CoV-2, or at least its genetic signature, abounds on hospital surfaces, often co-locating with one particular type of bacteria.
The SARS-CoV-2 papain-like protease (PLpro) plays an essential role in processing viral proteins needed for replication. In addition, the enzyme can cut and inactivate some human proteins important for an immune response. Now, researchers reporting in ACS Infectious Diseases have found other targets of PLpro in the human proteome, including proteins involved in cardiovascular function, blood clotting and inflammation, suggesting a link between the inactivation of these proteins and COVID-19 symptoms.
In a new study published in Nature, Dan Barouch, MD, PhD, Director of Beth Israel Deaconess Medical Center's Center for Virology and Vaccine Research, and colleagues report on the antibody and cellular immune responses generated by the Ad26.COV2.S vaccine against the original viral strain and against SARS-CoV-2 variants of concern. The team found that this vaccine induced immune responses against all the viral variants.