In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells.
A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia. The findings, published in Alzheimer's Research & Therapy, indicate an overlap between COVID-19 and brain changes common in Alzheimer's, and may help inform risk management and therapeutic strategies for COVID-19-associated cognitive impairment.
Much like a supply truck crossing the countryside, the misfolded proteins that damage neurons in Alzheimer's disease travel the "roads" of the brain, sometimes stopping and sometimes re-routing to avoid roadblocks, reports a study published in Science Advances by researchers at Van Andel Institute and University of Pennsylvania.
As deadly as it is, cancer metastasis is a poorly understood process. A new study led by Penn's Kamen Simeonov and Christopher Lengner describes a cutting-edge tool for tracing the lineage and gene expression of thousands of individual metastatic cancer cells. Their findings open new angles for investigating the processes that drive metastasis.
Until now, systemic biomarkers to measure exercise effects on brain function and that link to relevant metabolic responses were lacking. A study shows a memory biomarker, myokine Cathepsin B (CTSB), increased in older adults following a 26-week structured aerobic exercise training. The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer's.
The scientific world has been delving ever deeper into cancer, scourging for even the tiniest biomolecule that could amp up the cure for the deadly disease. A recent discovery in this regard is the gene LIM domain only 1, whose coded protein has a role in tumor formation. In a new article in Chinese Medical Journal, researchers have reviewed studies detailing molecular features of this gene for potential practical applications in cancer cure.
An international team of researchers have shed new light on the early stages of viral evolution.
This study will benefit scientists and experts in brain research where new discoveries of biomarkers are needed to form part of routine clinical practice protocols. The study relies on zebrafish Parkinson's Disease model, showing how cytosolic dsDNA of mitochondrial origin can accumulate in brains cells thereby contributing to PD pathogenesis. The evidence presented in this manuscript illustrates that upregulation of DNAse II can counteract the dsDNA deposits, thereby blocking the IFI16-mediated cascade of proinflammatory responses.
Researchers from Aarhus University and University of Copenhagen have developed a new method, which makes CRISPR gene editing more precise than conventional methods. The method selects the molecules best suited for helping the CRISPR-Cas9 protein with high-precision editing at the correct location in our DNA, the researchers explain.
Scientists are hoping the RNA of an obscure infection can one day be used like a Trojan horse to deliver life-saving treatments to citrus trees.