Mesenchymal stem cells are the origin for osteoblasts, but MSC transplantation has not resulted in long-term success as a treatment option for brittle bone disease. Hematopoietic stem cells usually give rise to blood cells and osteoclasts, but researchers hypothesized that they could give rise to osteoblasts too. By replacing osteoblasts, they offer a potential therapeutic opportunity that is not dependent on a specific mutation but simply on a mutation being present, which gives patients hope.
Transplanting hematopoietic stem cells to treat cancers and other conditions carries with it the risk of developing cardio-cerebrovascular diseases (CCVD)--disorders affecting the blood vessels of the heart and brain. Although research on post-transplant CCVD is extensive, there is paucity of knowledge on the effects of pre-transplant CCVD on transplant outcomes. Now researchers in China suggest pre-transplant CCVD indirectly affects patient mortality and survival following transplant through their strong association with post-transplant CCVD.
Scientists have developed a 'nanobody' - a small fragment of a llama antibody - that is capable of chasing out human cytomegalovirus (HCMV) as it hides away from the immune system. This then enables immune cells to seek out and destroy this potentially deadly virus.
Changes to the US kidney allocation system could result in reduced access to kidney transplants and longer times spent in line for rural patients according to new research. The OPTN addressed allocation inequalities by ensuring that all patients wait at least the same amount of time for a kidney rather than the previous geography-based model. These policy changes are also predicted to result in a 40% decline in kidney transplant volumes for South Carolina.
An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science.
This new review by the International Osteoporosis Foundation (IOF) and European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) CKD-MBD working group provides concise recommendations, with a clear management algorithm, to support clinicians' knowledge and confidence in managing osteoporosis in their patients with chronic kidney disease stages 4-5D.
It's a supply and demand problem, it's a transportation problem, it's a donor problem - and that just scratches the surface. According to the Organ Procurement and Transplantation Network, every 9 minutes a new patient is added to the organ waiting list. Every day 17 people die waiting for a kidney transplant. New research in the INFORMS journal Management Science tackles the transportation part of this problem.
In a new article, researchers address some of the ethical decisions that go into decisions to split a liver and provide a model to help hospitals make SLT decisions.
A transplant of healthy gut microbes followed by fibre supplements benefits patients with severe obesity and metabolic syndrome, according to University of Alberta clinical trial findings published today in Nature Medicine.
NYU Abu Dhabi (NYUAD) researchers uncovered a code that sets the genome of the liver to account for the remarkable ability for this organ to regenerate. This finding offers new insight into how the specific genes that promote regeneration can be activated when part of the liver is removed. These findings have the potential to inform the development of a new form of regenerative medicine that could help non-regenerative organs regrow in mice and humans.