"This discovery furthers our understanding of how Borrelia burgdorferi causes inflammation and disease," said Mari Davis, who is the lead author on the paper, a former master's graduate of the Jutras lab in the Department of Biochemistry in the College of Agriculture and Life Sciences. "It is a testament to how unique that this bacterium is -- and how we need to keep working to understand more about what is going on behind the scenes in order to develop future diagnostics and treatments."
All modern life is cellular, but how life came to be cellular remains uncertain. New research shows that simple chemical compounds known as hydroxy acids, which were likely common on primitive Earth, spontaneously link together and form structures reminiscent of cells when dried from solution, as may have happened on primitive beaches. The resulting structures may have helped scaffold the emergence of biological cellularity, and offer scientists a new avenue for studying early proto-biological evolution.
Scientists at Scripps Research have unveiled a new Ebola virus vaccine design, which they say has several advantages over standard vaccine approaches for Ebola and related viruses that continue to threaten global health. In the new design, described in a paper in Nature Communications, copies of the Ebola virus outer spike protein, known as the glycoprotein, are tethered to the surface of a spherical carrier particle.
Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions. Now, researchers reporting in ACS' Journal of Medicinal Chemistry have developed a peptide that, in mice, allowed Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, to fight pain without the side effects.
There is no long-term benefit to surgically placing tubes in a young child's ears to reduce recurrent ear infections, compared with giving oral antibiotics, a randomized trial determined.
A new study led by the Centre for Nutraceuticals in the University of Westminster shows that pink drinks can help to make you run faster and further compared to clear drinks.
University of Chicago Asst. Prof. Mark Levin and his team have discovered a way to create new molecules by cutting nitrogen atoms from molecules.
Recently, the Oxford University and Pfizer and BioNTech made SARS-CoV-2 vaccines through targeting the spike protein gene. The US Food and Drug Administration (FDA) and the health authorities of the United Kingdom approved and started vaccination using the Pfizer and BioNTech mRNA vaccine. Also, The FDA of USA approved the treatment of COVID-19 using two monoclonal antibodies produced by Regeneron pharmaceuticals to target the spike protein.
Inappropriate antibiotic prescribing for upper respiratory tract infections contributes to antibiotic resistance, making some bacterial infections difficult to treat. This often leads to higher medical costs, prolonged hospital stays and increased mortality. Still, many physicians report prescribing antibiotics at their patients' request. To address patients' expectations for antibiotic prescribing for URTIs, researchers conducted an experiment in which study participants were assigned brief educational videos to watch on a tablet immediately prior to their appointment.
It's widely understood that people taking a common class of antibiotics, like ciprofloxacin and levofloxacin, run the risk of tendonitis and tendon ruptures. However, a new analysis sheds light on newer, third-generation fluoroquinolones and suggests they may have a lower risk of Achilles tendon rupture.