The body's so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury. This HDL protects the liver by blocking inflammatory signals produced by common gut bacteria.
With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is conducted in mice and human liver tissue, shows that the degeneration of nerves is correlated with the severity of liver pathology. The results are being published in the journal Science Advances.
An RNA modification may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver and can lead to advanced liver disease, according to a new study by UCLA researchers. The modification may also explain why females tend to have higher fat content in the liver.
A preclinical study offers hope for treatment of uveal melanoma, a rare and deadly cancer of the eye. A small molecule inhibitor has been identified that dampens the potent drivers of this tumor. In mouse models, the inhibitor strongly limited primary disease in the eye and metastatic tumor dissemination to the liver, and animals survived longer, without overt side effects.
A team of University of Houston pharmaceutical researchers is reporting a newly recognized process of drug metabolism in the intestines - followed by recycling through the liver - that could have important implications for developing treatments for intestinal diseases and for taking multiple medications at the same time.
Irritable bowel syndrome (IBS) is prevalent in China, where much research has been conducted on this condition. However, most of these studies are published in Chinese, and their findings remain inaccessible to western scientists. To address this problem, a pair of researchers have published a review article on the Chinese Medical Journal condensing Chinese IBS studies carried out over the past decade. This review will help promote and guide future research efforts on IBS.
Researchers revealed how non-alcoholic fatty liver disease can develop into a life-threatening complication. Their discovery will accelerate the search for therapeutic solutions. The study was led by Helmholtz Zentrum München in collaboration with the Heidelberg University Hospital and the German Center for Diabetes Research.
UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease.
In a new article, researchers address some of the ethical decisions that go into decisions to split a liver and provide a model to help hospitals make SLT decisions.
Russian and Ukrainian scientists have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies -- among pest control chemicals. In addition, the team looked at modifications of the medication called hymecromone, deeming them promising for anti-fibrotic drugs, too. Published in Glycobiology, the study also sheds light on the possible mechanism of action of the investigated compounds, all of which inhibit the synthesis of hyaluronic acid.