In a study carried out in mice at the University of Chicago, researchers found that lasofoxifene outperformed fulvestrant, the current gold-standard drug, in reducing or preventing primary tumor growth.
In the largest study of the associations between smoking and cardiovascular disease on cognitive function, researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, found both impair the ability to learn and memorize; and that the effects of smoking are more pronounced among females, while males are more impaired by cardiovascular disease. The results appear today in the journal Scientific Reports.
The relevance of pet dog biobanking in molecular research and the initiative to make pioneering steps in this field. The Hungarian Canine Brain and Tissue Bank (CBTB) was established by the research team of the Senior Family Dog Project in 2017, following the examples of human tissue banks. In a recent paper, the team reports findings, which would not have been possible without the CBTB, and may augment further progress in dog aging and biomarker research.
In a new study, researchers with the ASU-Banner Neurodegenerative Disease Center at the Biodesign Institute and their colleagues investigate tangles in the brain -- pathologies not only characteristic of Alzheimer's but other neurodegenerative conditions as well. The research homes in on a particular protein known as Rbbp7, whose dysregulation appears linked to the eventual formation of tau protein tangles and the rampant cell death associated with Alzheimer's and other neurodegenerative diseases.
EAST LANSING, Mich. - An acute loss of smell is one of the most common symptoms of COVID-19, but for two decades it has been linked to other maladies among them Parkinson's disease and dementia. Now, a poor sense of smell may signify a higher risk of pneumonia in older adults, says a team of Michigan State University researchers.
Social isolation among older adults is associated with poor health and premature mortality, but the connection between social isolation and physical functioning is poorly understood. New research generates more robust evidence about the associations between social isolation and physical functioning and how this accelerates over time, reports the American Journal of Preventive Medicine, published by Elsevier. It also highlights the importance of incorporating strategies to reduce social isolation and promote successful aging.
The research offers some of the first clear guidance on the most effective methods to perform testing to detect COVID-19 in wastewater.
Contrary to popular belief, a new study from the University of Chicago Medicine found the frequency of abdominal surgery in older adults is decreasing, especially among adults over the age of 85.
Research from life-saving charity Air Ambulance Kent Surrey Sussex (KSS) and the University of Surrey indicates that the criteria for immediate Helicopter Emergency Medical Services (HEMS) dispatch to older trauma patients should be reviewed.
Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct -- or senescent -- cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy.