Preclinical trials of a new radiopharmaceutical to treat ovarian cancer have produced successful results, dramatically limiting tumor growth and decreasing tumor mass. Designed specifically for ovarian cancers that are resistant to traditional therapies, the new radiopharmaceutical can be produced in 25 minutes at low cost, which leads to better efficiency compared with alternative methods. This research was presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting.
3D tumors that disintegrate within a few days thanks to the action of a well-known omega-3 (DHA, found mainly in fish) -- this is the exceptional discovery by University of Louvain researchers. Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die.
Lab animals deficient in vitamin D crave and become dependent on opioids, which is curbed when normal levels of the vitamin are restored. Human health records indicate that people with low vitamin D are more likely to use and misuse opioids. Study results suggest a potential role for vitamin D supplementation in fighting opioid addiction.
The importance of complex networks of heterotypic interactions between multiple distinct cell types (both malignant and normal) and regulatory circuits has now become widely recognized.
Ketogenic metabolic therapy has been shown to successfully starve cancer cells of the glucose and glutamine they need to survive. In a new case study, a British man who rejected the standard of care to treat his glioblastoma has lived for more than 80 months with the typically fatal tumor after adopting a ketogenic diet, researchers report in the journal Frontiers in Nutrition
As deadly as it is, cancer metastasis is a poorly understood process. A new study led by Penn's Kamen Simeonov and Christopher Lengner describes a cutting-edge tool for tracing the lineage and gene expression of thousands of individual metastatic cancer cells. Their findings open new angles for investigating the processes that drive metastasis.
AP-HP Greater Paris University Hospitals and Owkin announced the recent results of their ongoing strategic collaboration at ASCO 2021. Their abstract demonstrates the first AI-based tool for predicting genomic subtypes of pancreatic cancer (PDAC) developed from machine learning applied to histology slides. The tool, a trained and validated AI model, is usable in clinical practice worldwide and opens the possibility of patient molecular stratification in routine care and for clinical trials.
A Ludwig Cancer Research study adds to growing evidence that immune cells known as macrophages inhabiting the body cavities that house our vital organs can aid tumor growth by distracting the immune system's cancer-killing CD8+ T cells.
Scientists say naked mole rats - a rodent native to West Africa - may hold the key to new treatments for degenerative diseases such as cancer and dementia.
Black people have a higher risk of colorectal cancer than white people, but this risk is likely not due to genetics. Data from a recent study by researchers from the US Department of Veterans Affairs, Regenstrief Institute and Indiana University School of Medicine adds more data to the existing evidence.