There is an urgent need to develop and implement effective screening, diagnosis and treatment strategies for patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), common liver conditions with a rising burden in the U.S. and globally. This is particularly important for the most at-risk patients, those with diabetes and obesity.
The body's so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury. This HDL protects the liver by blocking inflammatory signals produced by common gut bacteria.
Hydrogels developed at Rice University mimic intestines when lined with epithelial cells. A study by Rice and Baylor College of Medicine proved hydrogels in various stiffnesses are valuable for learning the dynamics of pathogens that cause diarrhea and other intestinal diseases.
Researchers from Tokyo Medical and Dental University (TMDU) have found that immunoglobulin A (IgA) deficiency leads to disruption of the ileal gut microbiota and increased inflammation in the ileum in mice. This suggests that IgA plays an important role in mucosal homeostasis by regulating the intestinal microbiota and protecting against mucosal inflammation, especially in the ileum
Researchers at Vanderbilt University Medical Center (VUMC) and the Baylor College of Medicine in Houston, Texas, have taken a big step toward developing targeted treatments and vaccines against a family of viruses that attacks the gastrointestinal tract.
A team of University of Houston pharmaceutical researchers is reporting a newly recognized process of drug metabolism in the intestines - followed by recycling through the liver - that could have important implications for developing treatments for intestinal diseases and for taking multiple medications at the same time.
Infant boys with a higher composition of a particular gut microbiota show enhanced neurodevelopment, according to a new University of Alberta-led study.
Irritable bowel syndrome (IBS) is prevalent in China, where much research has been conducted on this condition. However, most of these studies are published in Chinese, and their findings remain inaccessible to western scientists. To address this problem, a pair of researchers have published a review article on the Chinese Medical Journal condensing Chinese IBS studies carried out over the past decade. This review will help promote and guide future research efforts on IBS.
Researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.
By implementing a long-term, prospective approach to the development of celiac disease, researchers have identified substantial microbial changes in the intestines of at-risk infants before disease onset.